A simple, noninvasive and efficient method for transdermal delivery of siRNA

  title={A simple, noninvasive and efficient method for transdermal delivery of siRNA},
  author={Chang-min Lin and Keng Yen Huang and Yang Zeng and Xian-cai Chen and Sen Wang and Yu Li},
  journal={Archives of Dermatological Research},
Effective delivery of therapeutic agents is the most challenging hurdle in the use of RNA interference for research and in the clinic. Here, we assessed whether a short synthetic peptide, ACSSSPSKHCG (TD-1), could be transported through rat footpad (follicle-free) skin and efficiently deliver small interfering RNA (siRNA) to knock down a target gene. Fluorescence microscopy revealed that topical co-administration of FITC-labeled TD-1 and FAM-labeled siRNA distributed uniformly from the… CONTINUE READING


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