A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.
@article{Guindon2003ASF, title={A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.}, author={S. Guindon and O. Gascuel}, journal={Systematic biology}, year={2003}, volume={52 5}, pages={ 696-704 } }
The increase in the number of large data sets and the complexity of current probabilistic sequence evolution models necessitates fast and reliable phylogeny reconstruction methods. We describe a new approach, based on the maximum- likelihood principle, which clearly satisfies these requirements. The core of this method is a simple hill-climbing algorithm that adjusts tree topology and branch lengths simultaneously. This algorithm starts from an initial tree built by a fast distance-based method… CONTINUE READING
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