A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.

Abstract

Mitochondrial dysfunction and oxidative stress are determinant events in the pathogenesis of nonalcoholic steatohepatitis. Silybin has shown antioxidant, anti-inflammatory, and antifibrotic effects in chronic liver disease. We aimed to study the effect of the silybin-phospholipid complex (SILIPHOS) on liver redox balance and mitochondrial function in a… (More)
DOI: 10.1124/jpet.109.161612

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@article{Serviddio2010ASC, title={A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.}, author={Gaetano Serviddio and Francesco Bellanti and Anna Maria Giudetti and Gabriele Vincenzo Gnoni and Antonio Petrella and Rosanna Tamborra and Antonio Romano and Tiziana Rollo and Gianluigi Vendemiale and Emanuele Altomare}, journal={The Journal of pharmacology and experimental therapeutics}, year={2010}, volume={332 3}, pages={922-32} }