A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.

@article{Wang2009ASJ,
  title={A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.},
  author={Yuan-Hung Wang and S Z Yeh and Kun-Hung Shen and Cheng-Huang Shen and G D Juang and Ling-I Hsu and H H Chiou and C. -J. Chen},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={241 1},
  pages={
          111-8
        }
}
Cigarette smoking, arsenic and occupational exposures are well-known risk factors for the development of urothelial carcinoma (UC). Therefore, the aim of this study is to investigate whether the effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures on risk of UC could be modified by genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase omega. A hospital-based case-control study consisted of 520 histologically confirmed UC cases, and 520 age… CONTINUE READING
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