Corpus ID: 26226855

A significant methotrexate-glutamine pharmacokinetic interaction.

  title={A significant methotrexate-glutamine pharmacokinetic interaction.},
  author={Scott L. Charland and David L. Bartlett and Michael H. Torosian},
  volume={11 2},
Previous studies indicate that glutamine-supplemented diets decrease the enterocolitis associated with methotrexate administration. The influence of glutamine on the pharmacokinetics of methotrexate and the formation of its major hepatic metabolite, 7-hydroxy-methotrexate was examined in 36 adult, female Lewis rats. Animals were randomly assigned to receive either a 3% glycine-supplemented solid diet (GLY; 25.0% protein; 17.6 kJ/g, or 4.2 kcal/g) or a 3% glutamine-supplemented solid diet (GLN… Expand

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