A significant effect of the TSPY1 copy number on spermatogenesis efficiency and the phenotypic expression of the gr/gr deletion.

@article{Shen2013ASE,
  title={A significant effect of the TSPY1 copy number on spermatogenesis efficiency and the phenotypic expression of the gr/gr deletion.},
  author={Ying Shen and Yuanlong Yan and Yunqiang Liu and Sizhong Zhang and Dong Yang and Peng Zhang and Lei Erbao Li and Yan Wang and Yongxin Ma and D. W. Tao and Yuan Yang},
  journal={Human molecular genetics},
  year={2013},
  volume={22 8},
  pages={1679-95}
}
AZFc deletions cause a significant phenotypic heterogeneity with respect to spermatogenesis; however, the reason for this is poorly understood. Recently, testis-specific protein Y-encoded 1 (TSPY1) copy number variation (CNV) was determined to be a potential genetic modifier of spermatogenesis. We performed a large-scale cohort study to investigate the effect of TSPY1 CNV on spermatogenesis and to elucidate the possible contribution of TSPY1 genetic variation to the phenotypic expression of… CONTINUE READING