A signature-based method for indexing cell cycle phase distribution from microarray profiles

@article{Mizuno2008ASM,
  title={A signature-based method for indexing cell cycle phase distribution from microarray profiles},
  author={Hideaki Mizuno and Yoshito Nakanishi and Nobuya Ishii and Akinori Sarai and Kunio Kitada},
  journal={BMC Genomics},
  year={2008},
  volume={10},
  pages={137 - 137}
}
The cell cycle machinery interprets oncogenic signals and reflects the biology of cancers. To date, various methods for cell cycle phase estimation such as mitotic index, S phase fraction, and immunohistochemistry have provided valuable information on cancers (e.g. proliferation rate). However, those methods rely on one or few measurements and the scope of the information is limited. There is a need for more systematic cell cycle analysis methods. We developed a signature-based method for… CONTINUE READING

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