A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

  title={A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.},
  author={Karim S Echtay and Telma C Esteves and Julian L. Pakay and Mika B. Jekabsons and Adrian J Lambert and Manuel Portero-Ot{\'i}n and Reinald Pamplona and Antonio Vidal-Puig and Steven Wang and Stephen J. Roebuck and Martin D. Brand},
  journal={The EMBO journal},
  volume={22 16},
Oxidative stress and mitochondrial dysfunction are associated with disease and aging. Oxidative stress results from overproduction of reactive oxygen species (ROS), often leading to peroxidation of membrane phospholipids and production of reactive aldehydes, particularly 4-hydroxy-2-nonenal. Mild uncoupling of oxidative phosphorylation protects by decreasing mitochondrial ROS production. We find that hydroxynonenal and structurally related compounds (such as trans-retinoic acid, trans-retinal… CONTINUE READING
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