A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells.

@article{Tomasoni2011ASL,
  title={A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells.},
  author={Romana Tomasoni and Sara Negrini and Stefania Fiordaliso and Andrijana Klajn and Tatiana Tkatch and Anna Mondino and Jacopo Meldolesi and Rosalba D'Alessandro},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 18},
  pages={3174-86}
}
The RE-1-specific silencing transcription factor (REST or NRSF) is a transcription repressor that orchestrates differentiation and also operates in differentiated neurons and neurosecretory cells (neural cells). Its role in proliferation has been investigated so far only in rapidly growing tumors, with conflicting results: suppression in non-neural tumors, stimulation in medulloblastomas. Working with two clones of chromaffin-neuronal PC12 cells, which express different levels of REST, and… CONTINUE READING

Citations

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REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.

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References

Publications referenced by this paper.
Showing 1-10 of 71 references

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Proceedings of the National Academy of Sciences of the United States of America • 1976
View 3 Excerpts
Highly Influenced

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 1 Excerpt

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