A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

@article{Standring1988ASP,
  title={A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.},
  author={David N. Standring and J. H. Ou and Frank R. Masiarz and William J. Rutter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 22},
  pages={
          8405-9
        }
}
Using synthetic hepatitis B virus (HBV) mRNAs, we have shown that expression of HBV core-antigen gene sequences in Xenopus oocytes leads to the stable accumulation of 21-kDa cytoplasmic core protein (P21). In contrast, expression of precore plus core sequences leads mainly to the secretion of a heterogeneous population of proteins ranging in size from 15 to 22 kDa that collectively display viral e antigen (HBeAg) activity. We demonstrate that the precore region contains a cleavable 19 amino… CONTINUE READING

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