A shotgun antisense approach to the identification of novel essential genes in Pseudomonas aeruginosa

  title={A shotgun antisense approach to the identification of novel essential genes in Pseudomonas aeruginosa},
  author={Ruggero Rusmini and Davide Vecchietti and Raffaella Macchi and Faustino Vidal-Aroca and Giovanni Bertoni},
  journal={BMC Microbiology},
  pages={24 - 24}
BackgroundAntibiotics in current use target a surprisingly small number of cellular functions: cell wall, DNA, RNA, and protein biosynthesis. Targeting of novel essential pathways is expected to play an important role in the discovery of new antibacterial agents against bacterial pathogens, such as Pseudomonas aeruginosa, that are difficult to control because of their ability to develop resistance, often multiple, to all current classes of clinical antibiotics.ResultsWe aimed to identify novel… 

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A shotgun antisense approach to the identification of novel essential genes in Pseudomonas aeruginosa

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