A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis.

@article{Eddleston2009AST,
  title={A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis.},
  author={Alison Eddleston and Massimo Marenzana and Adrian Moore and Paul Stephens and Mariusz Muzylak and Diane Marshall and Martyn K. Robinson},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 10},
  pages={
          1662-71
        }
}
Chronic inflammation leads to bone loss, and increased fracture rates have been reported in a number of human chronic inflammatory conditions. The study reported here investigates the skeletal effects of dosing a neutralizing antibody to the bone regulatory protein sclerostin in a mouse model of chronic colitis. When dosed prophylactically, an antibody to sclerostin (Scl-AbI) did not reduce the weight loss or histological changes associated with colitis but did prevent inflammation-induced bone… CONTINUE READING
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