A short-term mechanism of plasticity for interneurones?

  title={A short-term mechanism of plasticity for interneurones?},
  journal={The Journal of physiology},
  volume={511 (Pt 2)},
  • McBain
  • Published 1998 in The Journal of physiology
AMPA-preferring glutamate receptors lacking the GluR2 subunit are highly permeable to Ca2+ ions. Ca2+ permeability is controlled by a single amino acid in the second membrane-associated domain, the so-called 'Q/R-site'. In addition to Ca2+ permeability, the Q/R site influences the sensitivity of the receptor complex to block by polyamine spider toxins and internal polyamines. The voltage-dependent block by internal polyamines gives rise to inward rectification of AMPA receptors lacking the… CONTINUE READING