A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity.

@article{Antoni1986ASS,
  title={A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity.},
  author={Giani D. Antoni and R Presentini and François P{\'e}rin and Aldo Tagliabue and Paolo Ghiara and Stefano Censini and Gianfranco Volpini and Luigi Villa and Diana Boraschi},
  journal={Journal of immunology},
  year={1986},
  volume={137 10},
  pages={3201-4}
}
Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an attempt to identify the minimal structure responsible for the immunostimulatory activity of IL 1. One of these peptides, a fragment of nine residues of human IL 1 beta (VQGEESNDK, fragment 163-171), showed high T cell activation capacity, as judged by its ability to stimulate murine thymocyte proliferation and to potently induce… CONTINUE READING

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