A short course on virology / vectorology / gene therapy.

@article{Debyser2003ASC,
  title={A short course on virology / vectorology / gene therapy.},
  author={Z. Debyser},
  journal={Current gene therapy},
  year={2003},
  volume={3 6},
  pages={
          495-9
        }
}
  • Z. Debyser
  • Published 2003
  • Biology, Medicine
  • Current gene therapy
For people starting off in the field of gene therapy, the encountered terminology is often quite confusing. Moreover, the background on basic virology may be modest. The following introduction provides a head start to any novice willing to gain more in-depth knowledge on the subject. The development of gene therapy is also addressed from a historical perspective. 
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References

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A key problem in gene therapy is the lack of a vector system that fulfils all the requirements for safety and efficacy, and viral vectors are the most promising vectors at this time. Expand
The basic science of gene therapy.
TLDR
A large number of key technical issues need to be resolved before gene therapy can be safely and effectively applied in the clinic, and future technological developments will be critical for the successful practice of gene therapy. Expand
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TLDR
A gene therapy trial for SCID-X1 was initiated, based on the use of complementary DNA containing a defective gammac Moloney retrovirus-derived vector and ex vivo infection of CD34+ cells, which provided full correction of disease phenotype and clinical benefit. Expand
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TLDR
These studies demonstrate the feasibility and safety of using retroviral gene transduction for human gene therapy and have implications for the design of TIL with improved antitumor potency, as well as for the possible use of lymphocytes for the gene therapy of other diseases. Expand
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