A short, stereocontrolled, and practical synthesis of alpha-methylomuralide, a potent inhibitor of proteasome function.

@article{Saravanan2003ASS,
  title={A short, stereocontrolled, and practical synthesis of alpha-methylomuralide, a potent inhibitor of proteasome function.},
  author={P Saravanan and E. J. Corey},
  journal={The Journal of organic chemistry},
  year={2003},
  volume={68 7},
  pages={2760-4}
}
An efficient and practical synthesis of alpha-methylomuralide (3), a selective inhibitor of proteasomes, has been developed as outlined in Scheme 1. Among the advantages of this route of synthesis over previously described approaches are (1) ease of scale-up and (2) high yields (28% overall yield of alpha-methylomuralide from 6) and stereocontrol (including… CONTINUE READING