A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

@article{Deng2015ASN,
  title={A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection},
  author={Weiwen Deng and Benjamin G Gowen and Li Zhang and Lin Lin Wang and Stephanie T Lau and Alexandre Iannello and Jianfeng Xu and Tihana Lenac Rovi{\vs} and Na Xiong and David H Raulet},
  journal={Science},
  year={2015},
  volume={348},
  pages={136-139}
}
Immune cells, including natural killer (NK) cells, recognize transformed cells and eliminate them in a process termed immunosurveillance. It is thought that tumor cells evade immunosurveillance by shedding membrane ligands that bind to the NKG2D-activating receptor on NK cells and/or T cells, and desensitize these cells. In contrast, we show that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection. Recombinant soluble MULT1 stimulated tumor… CONTINUE READING
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