A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface

@article{Shukla2010ASS,
  title={A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface},
  author={Sudhanshu Shukla and Ken-Ichi Fujita and Qi Xiao and Zhiyong Liao and Susan S. Garfield and Srinivasa M. Srinivasula},
  journal={Apoptosis},
  year={2010},
  volume={16},
  pages={162-173}
}
Cells that form vascular system employ different mechanisms to offset deleterious consequences of exposure to cytokines and cells present in blood. Vascular homeostasis is sustained in part by genes, whose expression increases in response to hemodynamic forces in these cells. PP1201 (also known as RECS1) is one such gene whose expression level increases in response to laminar shear stress. Aged mice deficient in PP1201 are prone to develop cystic medial degeneration (CMD), a form of aortic… CONTINUE READING
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