A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.


We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.

DOI: 10.1038/ng.649

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@article{Abnet2010ASS, title={A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.}, author={Christian C Abnet and Neal David Freedman and Nan Hu and Zhaoming Wang and Kai Yu and Xiao Shu and Jian-Min Yuan and Wei Zheng and Sanford M . Dawsey and Linda M. Dong and Maxwell P. Lee and Ti Ding and You-Lin Qiao and Yu-tang Gao and Woon-Puay Koh and Yong-Bing Xiang and Ze-Zhong Tang and Jin-hu Fan and Chaoyu Wang and William Wheeler and Mitchell H. Gail and Meredith Yeager and Jeff Yuenger and Amy A. Hutchinson and Kevin B. Jacobs and Carol A Giffen and Laurie A. Burdett and Joseph F. Jr. Fraumeni and Margaret A. Tucker and Wong-Ho Chow and Alisa M. Goldstein and Stephen J. Chanock and Philip R. Taylor}, journal={Nature genetics}, year={2010}, volume={42 9}, pages={764-7} }