A shape analysis method to detect dendritic spine in 3D optical microscopy image

@article{Xu2006ASA,
  title={A shape analysis method to detect dendritic spine in 3D optical microscopy image},
  author={Xiaoyin Xu and Jie Cheng and Rochelle M. Witt and Bernardo L. Sabatini and Stephen T. C. Wong},
  journal={3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006.},
  year={2006},
  pages={554-557}
}
Dendritic spines play an important role in synaptic transmission. Spines are small protrusions formed on the shafts of dendrites and they are manifest of many neurological conditions. Three dimensional images of dendrites and spines are obtained by confocal and two-photon laser scanning microscopy. We present an image processing method based on shape analysis to detect spines and separate spines from the dendrites for quantitative study. The method applies two grassfire procedures to first find… CONTINUE READING
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