A sex-specific role for androgens in angiogenesis

  title={A sex-specific role for androgens in angiogenesis},
  author={Daniel P. Sieveking and Patrick R. Lim and Ren{\'e}e W.Y. Chow and Louise L. Dunn and Shisan J. Bao and Kristine C.Y. McGrath and Alison Kay Heather and David J Handelsman and David S Celermajer and Martin K. C. Ng},
  booktitle={The Journal of experimental medicine},
Mounting evidence suggests that in men, serum levels of testosterone are negatively correlated to cardiovascular and all-cause mortality. We studied the role of androgens in angiogenesis, a process critical in cardiovascular repair/regeneration, in males and females. Androgen exposure augmented key angiogenic events in vitro. Strikingly, this occurred in male but not female endothelial cells (ECs). Androgen receptor (AR) antagonism or gene knockdown abrogated these effects in male ECs… CONTINUE READING
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