A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus.

@article{Pewe2005ASA,
  title={A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus.},
  author={Lecia L. Pewe and Haixia Zhou and Jason M. Netland and Chandra Tangudu and Heidi A. Olivares and Lei Shi and Dwight C. Look and Thomas Gallagher and Stanley Perlman},
  journal={Journal of virology},
  year={2005},
  volume={79 17},
  pages={11335-42}
}
Most animal species that can be infected with the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) do not reproducibly develop clinical disease, hindering studies of pathogenesis. To develop an alternative system for the study of SARS-CoV, we introduced individual SARS-CoV genes (open reading frames [ORFs]) into the genome of an attenuated murine coronavirus. One protein, the product of SARS-CoV ORF6, converted a sublethal infection to a uniformly lethal encephalitis and… CONTINUE READING