A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13–16.1

@article{Thys2007ASL,
  title={A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13–16.1},
  author={M. Thys and K. V. D. Bogaert and V. Iliadou and K. Vanderstraeten and N. Dieltjens and I. Schrauwen and W. Chen and N. Eleftheriades and M. Grigoriadou and R. Pauw and C. Cremers and R. Smith and M. Petersen and G. Camp},
  journal={European Journal of Human Genetics},
  year={2007},
  volume={15},
  pages={362-368}
}
Otosclerosis is a common form of hearing impairment among white adults with a prevalence of 0.3–0.4%. It is caused by abnormal bone homeostasis of the otic capsule that compromises free motion of the stapes in the oval window. Otosclerosis is in most patients a multifactorial disease, caused by both genetic and environmental factors. In some cases, the disease is inherited as a monogenic autosomal dominant trait, sometimes with reduced penetrance. However, families large enough for genetic… Expand
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