A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.

@article{Kavaler1990ASO,
  title={A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.},
  author={Joshua Kavaler and Andrew J. Caton and Louis M. Staudt and David P. Schwartz and Walter Gerhard},
  journal={Journal of immunology},
  year={1990},
  volume={145 7},
  pages={2312-21}
}
Approximately 50% of the primary antibody response of BALB/c mice to the A/PR/8/34 influenza virus hemagglutinin is directed to the Cb site, one of the four major antigenic regions of the molecule. To determine the structural basis of the anti-Cb site response, we have examined the paratypic and genetic diversity exhibited by a panel of 24 primary and 4 secondary response mAb specific for this antigenic region. Reactivity pattern analysis demonstrated 20 distinct fine specificities among these… CONTINUE READING

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