A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity

Abstract

Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for anti-cancer therapy. Previously, we reported that a hexapeptide (RRKRRR, RK6) blocked the growth and metastasis of tumor by inhibiting VEGF binding to its… (More)
DOI: 10.3858/emm.2010.42.7.052

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