A serum mannose-binding lectin mediates complement-dependent lysis of influenza virus-infected cells.

@article{Reading1995ASM,
  title={A serum mannose-binding lectin mediates complement-dependent lysis of influenza virus-infected cells.},
  author={Patrick C. Reading and Carol Anne Hartley and R . Alan B. Ezekowitz and E. Margot Anders},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={217 3},
  pages={1128-36}
}
The mechanism of lysis of influenza virus-infected BHK-21 cells by guinea pig serum (GPS) was investigated. Lysis was shown to involve activation of the classical complement pathway and was dependent on the presence of a mannose-binding lectin in GPS. FACS analysis demonstrated Ca(2+)-dependent binding of the lectin to influenza virus-infected, but not uninfected, cells. Cells infected with mutant strains of virus lacking a particular high-mannose oligosaccharide at the tip of the hemagglutinin… CONTINUE READING
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