A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide.

@article{Mann2000AST,
  title={A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide.},
  author={J. John Mann and Yolanda Y. Huang and Mark D. Underwood and Suham A Kassir and Steven Oppenheim and Thomas M. Kelly and Andrew J. Dwork and Victoria Arango},
  journal={Archives of general psychiatry},
  year={2000},
  volume={57 8},
  pages={729-38}
}
BACKGROUND Major depression and suicide are associated with fewer serotonin transporter (5-HTT) sites. The 5'-flanking promoter region of the 5-HTT gene has a biallelic insertion/deletion (5-HTTLPR). We assayed prefrontal cortical (PFC) 5-HTT binding in major depression and suicide and examine the relationship to the 5-HTTLPR allele. METHODS Postmortem brain samples from 220 individuals were genotyped for the 5-HTTLPR polymorphism. Binding of 5-HTT was assayed by quantitative autoradiography… CONTINUE READING
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