A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011

Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world. Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization… CONTINUE READING