A serine protease triad forms the catalytic centre of a triacylglycerol lipase

@article{Brady1990ASP,
  title={A serine protease triad forms the catalytic centre of a triacylglycerol lipase},
  author={Leo Brady and Andrzej Marek Brzozowski and Zygmunt S Derewenda and Eleanor J. Dodson and Guy G. Dodson and Shirley P. Tolley and Johan P. Turkenburg and Lars Christiansen and Birgitte Huge-Jensen and Leif Norskov and Lars Thim and Ulrich Dr. Menge},
  journal={Nature},
  year={1990},
  volume={343},
  pages={767-770}
}
TRUE Upases attack triacylglycerols and act at an oil–water interface; they constitute a ubiquitous group of enzymes catalysing a wide variety of reactions, many with industrial potential. But so far the three-dimensional structure has not been reported for any lipase. Here we report the X-ray structure of the Mucor miehei triglyceride lipase and describe the atomic model obtained at 3.1 Å resolution and refined to 1.9 Å resolution. It reveals a Ser .. His .. Asp trypsin-like catalytic triad… Expand
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