A series of enediynes as novel inhibitors of topoisomerase I.

@article{Lin2001ASO,
  title={A series of enediynes as novel inhibitors of topoisomerase I.},
  author={C F Lin and Pei chung Hsieh and Wei Dong Lu and Hui Fen Chiu and Ming Jung Wu},
  journal={Bioorganic & medicinal chemistry},
  year={2001},
  volume={9 7},
  pages={1707-11}
}
A series of acyclic enediynes, 2-((6-substituted)-3-hexen-1,5-diynyl)benzonitriles (8--11), display potent inhibition against topoisomerase I without the formation of active biradical intermediates and show inhibitory activity against topoisomerase I at 10 microM, which is five times that of camptothecin from the results of agarose gel electrophoresis.