A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.

@article{Gong2011ASO,
  title={A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.},
  author={Nian Gong and Zhen-yu Gao and Yan-chao Wang and Xin-Yan Li and Jin-lu Huang and Kenji Hashimoto and Yong-xiang Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={336 1},
  pages={282-93}
}
We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain. The present research further studied the analgesic effects of a series of DAO inhibitors in this model. 5-Chlorobenzo[d]isoxazol-3-ol (CBIO), 4H-thieno[3,2-b]pyrrole-5-carboxylic acid (compound 8), 5-methylpyrazole-3-carboxylic acid (AS057278), sodium benzoate, and 4-nitro-3-pyrazole carboxylic acid (NPCA) inhibited rat spinal cord-derived DAO activity in a concentration-dependent manner, with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

inventors; Sepracor, Inc., assignee. Pyrrole and pyrazole DAAO inhibitors

  • QK Fang, S Hopkins, M Heffernan, M Chytil
  • U.S. Patent 7488747
  • 2009
Highly Influential
8 Excerpts

, inventors ; Sepracor , Inc . , assignee . Pyrrole and pyrazole DAAO inhibitors . U . S . Patent 7488747

  • D Ferraris, B Duvall, +5 authors T Tsukamoto
  • 2008
Highly Influential
5 Excerpts

response in rats

  • T Adage, AC Trillat, +7 authors I Chumakov
  • 2008
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…