A series of C-terminal amino alcohol dipeptide A beta inhibitors.


Potent, small molecule A beta inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assay.

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@article{Garofalo2002ASO, title={A series of C-terminal amino alcohol dipeptide A beta inhibitors.}, author={Albert William Garofalo and David W G Wone and Angela Phuc and James E Audia and Cheryl A. Bales and Harry F. Dovey and Darren B Dressen and Beverly K Folmer and Erich G Goldbach and Ashley C Guinn and Lee H Latimer and Thomas E Mabry and Jeffrey S Nissen and Michael A Pleiss and Stephen A. Sohn and Eugene D Thorsett and Jay S. Tung and Jing Wu}, journal={Bioorganic & medicinal chemistry letters}, year={2002}, volume={12 21}, pages={3051-3} }