A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Abstract

Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to hepatic lineage undergoes a sequential EMT-MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals that Activin A-induced formation of definitive endoderm (DE… (More)
DOI: 10.1038/ncomms15166

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Cite this paper

@inproceedings{Li2017ASE, title={A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes}, author={Qiuhong Li and Andrew Paul Hutchins and Yong Chen and Shengbiao Li and Yongli Shan and B. S. Liao and Dejin Zheng and Xi Shi and Yinxiong Li and Wai-Yee Chan and Guangjin Pan and Shicheng Wei and Xiaodong Shu and Duanqing Pei}, booktitle={Nature communications}, year={2017} }