A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.

@article{Warfield2014AST,
  title={A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.},
  author={Linda Warfield and Lisa M. Tuttle and Derek Pacheco and Rachel E. Klevit and Steven Hahn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 34},
  pages={E3506-13}
}
Although many transcription activators contact the same set of coactivator complexes, the mechanism and specificity of these interactions have been unclear. For example, do intrinsically disordered transcription activation domains (ADs) use sequence-specific motifs, or do ADs of seemingly different sequence have common properties that encode activation function? We find that the central activation domain (cAD) of the yeast activator Gcn4 functions through a short, conserved sequence-specific… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS

6 Figures & Tables

Topics

Statistics

01020201620172018
Citations per Year

Citation Velocity: 8

Averaging 8 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.