A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.

@article{Verdier1998ASO,
  title={A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.},
  author={Fr{\'e}d{\'e}rique Verdier and Raquel Rabionet and Fabrice Gouilleux and Christian Beisenherz-Huss and Paule Varlet and Odile Muller and Patrick Mayeux and Catherine Lacombe and Sylvie Gisselbrecht and Stany Chr{\'e}tien},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 10},
  pages={5852-60}
}
Two distinct genes encode the closely related signal transducer and activator of transcription proteins STAT5A and STAT5B. The molecular mechanisms of gene regulation by STAT5 and, particularly, the requirement for both STAT5 isoforms are still undetermined. Only a few STAT5 target genes, among them the CIS (cytokine-inducible SH2-containing protein) gene, have been identified. We cloned the human CIS gene and studied the human CIS gene promoter. This promoter contains four STAT binding… CONTINUE READING

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