A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels.

@article{Stockklausner2001ASM,
  title={A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels.},
  author={Clemens Stockklausner and Jost Ludwig and Johann Peter Ruppersberg and Nikolaj Kl{\"o}cker},
  journal={FEBS letters},
  year={2001},
  volume={493 2-3},
  pages={129-33}
}
Integral membrane proteins are sorted via the secretory pathway. It was proposed that this pathway is non-selective provided that the cargo protein is properly assembled and lacks an endoplasmic reticulum (ER) retention signal. However, recent experimental evidence suggests that efficient export of proteins from the ER to the Golgi complex is not simply a default pathway. Here we demonstrate a novel sequence motif (FxYENEV) in the cytoplasmic C-terminus of mammalian inward rectifier potassium… CONTINUE READING

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