A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs.

@article{Salzler2013ASI,
  title={A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs.},
  author={Harmony R. Salzler and Deirdre C. Tatomer and Pamela Y Malek and Stephen L McDaniel and Anna N Orlando and William Bill F Marzluff and Robert J. Duronio},
  journal={Developmental cell},
  year={2013},
  volume={24 6},
  pages={623-34}
}
Compartmentalization of RNA biosynthetic factors into nuclear bodies (NBs) is a ubiquitous feature of eukaryotic cells. How NBs initially assemble and ultimately affect gene expression remains unresolved. The histone locus body (HLB) contains factors necessary for replication-coupled histone messenger RNA transcription and processing and associates with histone gene clusters. Using a transgenic assay for ectopic Drosophila HLB assembly, we show that a sequence located between, and transcription… CONTINUE READING

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