A sepsis risk calculator can decrease antibiotic exposure in neonatal early‐onset sepsis screening

  title={A sepsis risk calculator can decrease antibiotic exposure in neonatal early‐onset sepsis screening},
  author={Rebeca Cavazos and Monika S Patil and Kanekal Suresh Gautham},
  journal={Acta Paediatrica},
Early-onset neonatal sepsis (EONS) can have devastating consequences. Historically, clinicians treated at-risk patients with antibiotics while awaiting blood culture results. This strategy, however, resulted in substantial antibiotic overtreatment over the last three decades.1 Consequences of early antibiotic overexposure include microbiome alterations2,3 which are linked to development of asthma, food allergies and childhood obesity.4-7 Intrapartum antibiotic strategies have reduced the… 


Management of Neonates Born at ≥35 0/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis
The purpose in this clinical report is to provide a summary of the current epidemiology of neonatal sepsis among infants born at ≥35 0/7 weeks’ gestation and a framework for the development of evidence-based approaches to sepsi risk assessment among these infants.
A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis
Clinical care algorithms based on individual infant estimates of EOS risk derived from a multivariable risk prediction model reduced the proportion of newborns undergoing laboratory testing and receiving empirical antibiotic treatment without apparent adverse effects.
Stratification of Risk of Early-Onset Sepsis in Newborns ≥34 Weeks’ Gestation
It is possible to combine objective maternal data with evolving objective neonatal clinical findings to define more efficient strategies for the evaluation and treatment of EOS in term and late preterm infants.
Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010.
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CDC's updated guidelines for the prevention of perinatal group B streptococcal disease have been endorsed by the American College of Obstetricians and Gynecologists and the American Academy of Pediatrics and continue to be the cornerstones of early-onset GBS disease prevention.
Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?
This review is a broad survey of the factors affecting infant colonization and the downstream effects on gastrointestinal health and disease as well as nutritional and microbial therapies.
Early differences in fecal microbiota composition in children may predict overweight.
Aberrant compositional development of the gut microbiota precedes overweight, offering new possibilities for preventive and therapeutic applications in weight management.
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
It is shown that in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen-free mice.
Perinatal Programming of Asthma: The Role of Gut Microbiota
This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma.
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.