A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.

Abstract

Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regarding the genetics, expression, and… (More)
DOI: 10.1002/ijc.23551

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