A sensitive open field measure of anxiolytic drug activity.

  title={A sensitive open field measure of anxiolytic drug activity.},
  author={Donald R. Britton and Karen Thatcher Britton},
  journal={Pharmacology, biochemistry, and behavior},
  volume={15 4},
Anxiolytic drugs including diazepam (DZP), chlordiazepoxide (CDX), pentabarbitol (PB) and ethanol (EtOH) produce specific alterations in the behavior of fasted rats given access to a single food pellet secured in the center of a novel open field environment. These drugs increase the total amount of food eaten in a 15 min test and the mean amount eaten per approach to the food pedestal. This latter effect appears to be the more sensitive index of anxiolytic drug action and occurs at doses which… CONTINUE READING


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