A sensitive non-isotopic assay for acetylcholine receptor autoantibodies.

  title={A sensitive non-isotopic assay for acetylcholine receptor autoantibodies.},
  author={Rachel Hewer and Ian Price Matthews and Shu Shin Chen and Vivienne McGrath and Mich{\`e}le Evans and Emma Roberts and Sarah Nute and J. 0. Sanders and Jadwiga Furmaniak and Bernard Rees Smith},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={364 1-2},
BACKGROUND Detection and measurement of serum acetylcholine receptor autoantibodies (AChRAb) are useful in the diagnosis and management of myasthenia gravis (MG). An immunoprecipitation assay (IPA) based on AChR labelled with 125I-alpha bungarotoxin is widely used for measurement of AChRAb, but a non-isotopic assay of sensitivity and specificity comparable to IPA is not available as yet. METHODS A new AChRAb ELISA, which is based on the ability of AChRAb to compete with 3 different AChR… CONTINUE READING
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