A sensitive method for the determination of hydrochlorothiazide in serum by high pressure liquid chromatography.

  title={A sensitive method for the determination of hydrochlorothiazide in serum by high pressure liquid chromatography.},
  author={William T. Robinson and L Cosyns},
  journal={Clinical biochemistry},
  volume={11 4},
14 Citations
Simplified detection of hydrochlorothiazide in urine by thin-layer chromatography.
A new thin-layer chromatographic procedure for the detection of the antihypertensive/diuretic drug hydrochlorothiazide in human urine is described, which typically allows the screening of 25 urine samples within one hour.
Determination of trichlormethiazide in human plasma and urine by high-performance liquid chromatography
The high-performance liquid chromatographic assay method for the determination of trichlormethiazide (TCM) in human plasma and urine has the advantages of high sensitivity for plasma assay and high precision with a simple procedure for both Plasma and urine samples.
High-pressure liquid chromatographic determination of chlorothiazide and hydrochlorothiazide in plasma and urine: preliminary results of clinical studies.
Urinary excretion rates of both chlorothiazides and hydrochlorothiazide closely resemble their concentration profiles in plasma, and preliminary results of a clinical study in fasting male volunteers showed that the plasma levels and urinary excretion rate of chloroth Diazide peaked at 1-2 hr following a 500-mg oral dose and subsequently declined irregularly.
HPLC determination of benzthiazide in biologic material.
In three of four human subjects who received a 50 mg benzthiazide tablet the plasma concentrations were below the 10 ng ml-1 sensitivity limit of the assay, and the urinary recovery averaged less than one per cent of the dose.
Biopharmaceutical characteristics of a new propranolol/hydrochlorothiazide tablet combination.
In adult male beagles, 50 mg of HCT had no apparent effect on AUC, Cmax, Tmax, and T1/2 of propranolol administered concurrently and in man, INDERIDE and INDERide were shown to be similar in bioavailability to the reference formulations, i.e. the same amount of drugs administered as the separate tablets of INDERAL plus HYDRODIURIL.


GLC analysis of hydrochlorothiazide in blood and plasma.
On-column methylation with trimethylanilinium hydroxide in methanol was employed to convert hydrochlorothiazide and its bromo analog, which served as the internal standard, to their tetramethyl derivatives.
Determination of Hydrochlorothiazide in Urine
Hydrochlorothiazide may be determined in urine by extracting with ethyl acetate and either reacting directly with chromotropic acid or hydrolyzing first with alkali followed by diazotization and
ArticlesDetermination of Hydrochlorothiazide in Urine
  • 1960