A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA‐negative primary biliary cirrhosis

@article{Oertelt2007ASB,
  title={A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA‐negative primary biliary cirrhosis},
  author={Sabine Oertelt and Roman Rieger and Carlo Selmi and Pietro Invernizzi and Aftab A. Ansari and Ross L. Coppel and Mauro Podda and Patrick S. C. Leung and Merrill Eric Gershwin},
  journal={Hepatology},
  year={2007},
  volume={45}
}
The antimitochondrial response in primary biliary cirrhosis (PBC) is the most highly directed and specific self‐reacting antibody in human immunopathology. Originally, antimitochondrial antibodies (AMAs) were detected by indirect immunofluorescence (IIF) and found in approximately 90% of well‐documented patients with PBC. The introduction of recombinant autoantigens and the use of immunoblotting have increased the sensitivity and specificity of AMAs, and they are now considered positive in… Expand
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