A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.

Abstract

Uric acid (UA) is known to be a major biological antioxidant in plasma. However, there is a strong correlation between UA levels and cardiovascular risk. Recent studies suggest that in the intracellular environment, UA can become a prooxidant that causes endothelial dysfunction. For conducting detailed studies of UA's role in human pathogenesis, there is a… (More)
DOI: 10.1016/j.jchromb.2009.05.037

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@article{Kim2009ASA, title={A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.}, author={Kyung Mee Kim and George N Henderson and Xiaosen Ouyang and R F Frye and Yuri Y. Sautin and Daniel I. Feig and Richard J. Johnson}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2009}, volume={877 22}, pages={2032-8} }