A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria.

Abstract

We previously showed that bisarylbutadiyne (BADY), which has a conjugated diyne structure, exhibits an intense peak in the cellular Raman-silent region. Here, we synthesized a mitochondria-selective Raman probe by linking bisphenylbutadiyne with triphenylphosphonium, a well-known mitochondrial targeting moiety. This probe, named MitoBADY, has a Raman peak… (More)
DOI: 10.1016/j.bmcl.2014.11.080

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