A sense of time: how molecular clocks organize metabolism.

  title={A sense of time: how molecular clocks organize metabolism.},
  author={Akira Kohsaka and Joseph Bass},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={18 1},
The discovery of an internal temporal clockwork that coordinates behavior and metabolism according to the rising and setting of the sun was first revealed in flies and plants. However, in the past decade, a molecular transcription-translation feedback loop with similar properties has also been identified in mammals. In mammals, this transcriptional oscillator programs 24-hour cycles in sleep, activity and feeding within the master pacemaker neurons of the suprachiasmatic nucleus of the… CONTINUE READING
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