A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

@article{Chang1999ASP,
  title={A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.},
  author={B D Chang and Eugenia V. Broude and Milos Dokmanovic and Hongyan Zhu and A Ruth and Yongzhi Xuan and Eugene S. Kandel and Ekkehart Lausch and K. Christov and Igor B. Roninson},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={3761-7}
}
Exposure of human tumor cell lines to different chemotherapeutic drugs, ionizing radiation, and differentiating agents induced morphological, enzymatic, and ploidy changes resembling replicative senescence of normal cells. Moderate doses of doxorubicin induced this senescence-like phenotype (SLP) in 11 of 14 tested cell lines derived from different types of human solid tumors, including all of the lines with wild-type p53 and half of p53-mutated cell lines. SLP induction seemed to be… CONTINUE READING
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Inde - pendent induction of senescence by p 16 INK 4 a and p 21 CIP 1 in spontaneously immortalized human fibroblasts

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