A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction.

@article{Gordi2005ASP,
  title={A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction.},
  author={Toufigh Gordi and Rujia Xie and Nguyen van Huong and Dinh Xuan Huong and Mats O. Karlsson and Michael Ashton},
  journal={British journal of clinical pharmacology},
  year={2005},
  volume={59 2},
  pages={189-98}
}
AIMS Previous studies have shown that the antimalarial drug artemisinin is a potent inducer of its own metabolism in both patients and healthy subjects. The aim of this study was to characterize the time-dependent pharmacokinetics of artemisinin in healthy subjects. METHODS Twenty-four healthy males were randomized to receive either a daily single dose of 500 mg oral artemisinin for 5 days, or single oral doses of 100/100/250/250/500 mg on each of the first 5 days. Two subjects from each… CONTINUE READING
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