A semiautomated measure of whole-brain atrophy in multiple sclerosis.

@article{Bermel2003ASM,
  title={A semiautomated measure of whole-brain atrophy in multiple sclerosis.},
  author={Robert Bermel and Jitendra Sharma and Christopher W. Tjoa and Srinivas Reddy Puli and Rohit Bakshi},
  journal={Journal of the neurological sciences},
  year={2003},
  volume={208 1-2},
  pages={57-65}
}
Brain atrophy is a proposed MRI marker of irreversible pathologic damage in multiple sclerosis (MS). The brain parenchymal fraction (BPF) is the ratio of brain parenchymal volume to the total volume within the surface contour. We developed a semiautomated measure of BPF using commercially available edge-finding and thresholding software (30-min analysis time per patient). We measured BPF in 78 patients with MS and 17 healthy controls. BPF was lower in a cohort of patients with MS (n=50) (0.843… CONTINUE READING
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