A semi-synthetic repertoire of intrinsically stable antibody fragments derived from a single-framework scaffold.

Abstract

We report the design, construction and use of an antibody bacteriophage display library built on the scaffold of a single-chain variable fragment (scFv) previously proven to be functionally expressed in the reducing environment of both bacterial and plant cytoplasm and endowed with intrinsic high thermodynamic stability. Four amino acid residues of the… (More)

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